TRIM27 (tripartite motif containing 27)
نویسندگان
چکیده
منابع مشابه
TRIM 37 ( tripartite motif - containing 37 )
Hugo: TRIM37 Other names: MUL; KIAA0898; POB1; TEF3 Location: 17q23.2 Local order: Genes flanking TRIM37 oriented from centromere to telomere on 17q23 are: RAD51C, 17q22-q23, D51 homolog C (S. Cerevisiae) PPM1E, 17q23.2, protein phosphatase 1E (PP2C domain containing) TRIM37, 17q22-q23, tripartite motif-containing 37 FAM33A 17q23.2, family with sequence similarity 33, member A PRR11(FLJ11029) 1...
متن کاملRole of the tripartite motif protein 27 in cancer development.
BACKGROUND The tripartite motif family protein 27 (TRIM27) is a transcriptional repressor that interacts with, and attenuates senescence induction by, the retinoblastoma-associated protein (RB1). High expression of TRIM27 was noted in several human cancer types including breast and endometrial cancer, where elevated TRIM27 expression predicts poor prognosis. Here, we investigated the role of TR...
متن کاملAntibodies mediate intracellular immunity through tripartite motif-containing 21 (TRIM21).
Antibodies provide effective antiviral immunity despite the fact that viruses escape into cells when they infect. Here we show that antibodies remain attached to viruses after cell infection and mediate an intracellular immune response that disables virions in the cytosol. We have discovered that cells possess a cytosolic IgG receptor, tripartite motif-containing 21 (TRIM21), which binds to ant...
متن کاملTripartite Motif-Containing 29 Expression in Squamous Cell Carcinoma
Received August 9, 2012, Revised September 3, 2012, Accepted for publication September 9, 2012 Corresponding author: Moon-Kyun Cho, M.D., Department of Dermatology, Soonchunhyang University Seoul Hospital, 59 Daesagwan-ro, Yongsan-gu, Seoul 140-743, Korea. Tel: 82-2-709-9368, Fax: 82-2-709-9374, E-mail: [email protected] This is an Open Access article distributed under the terms of the Crea...
متن کاملTripartite motif containing protein 27 negatively regulates CD4 T cells by ubiquitinating and inhibiting the class II PI3K-C2β.
The K(+) channel KCa3.1 is required for Ca(2+) influx and the subsequent activation of CD4 T cells. The class II phosphatidylinositol 3 kinase C2β (PI3KC2β) is activated by the T-cell receptor (TCR) and is critical for KCa3.1 channel activation. Tripartite motif containing protein 27 (TRIM27) is a member of a large family of proteins that function as Really Interesting New Gene (RING) E3 ubiqui...
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ژورنال
عنوان ژورنال: Atlas of Genetics and Cytogenetics in Oncology and Haematology
سال: 2015
ISSN: 1768-3262
DOI: 10.4267/2042/56441